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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed87588241703a9b3f9da257dd7b243ff037ea6f6c521439aeff045fe0b18793' 
  AND token = 'Vc0LkJRSK+uEjbeeA/OXAafBUHA18W/4YsPjqTolEFE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}