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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50af0f5f6f80c64f316a70fd8ff02738a0dbef73d3e195103d22e589e02c6888' 
  AND token = '6nrPPJmP3FQzbrd59tBihaMVfoKKqIVwpgTYgbreaho=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}