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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd5456656dbb55b992b9a21b83a2014b878fb4da632a8e8eaf5ba8ad7fe9e2337' 
  AND token = 'GM9Gd15+V/A645CcFnnr4zNfbD5AOjW/DdOrLKoUwW8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}