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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42ea0fb21470af23b48e237e3cfc55b5f5303439bdc864be6ef1b16021e987ac' 
  AND token = 'IoUvV18bckHYXL9OS9vUrENjJx2dOlpLvjtMeXt6Cfw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}