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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65066cc27ef9bd1de30721389e87be3c3e53c82d057bf1df330ac5ddf403c615' 
  AND token = 'tysg8Gl3cciCwBgvvDDiJP+rFhExS80Ua2Wpq0qup3Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}