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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a42a5b13ed15f8e7c9ff5ecc479a89dd7f325f31025486012c65b8dca6c1ff49' 
  AND token = 'Uo+Pmf0UIdamYxqDL+oG4UK+Up16SqkWiHZe3wfGRSw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}