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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '481a3bc4c2a3778231e0afd0544c366ccd34ede05f45515d42fb7ed900840ada' 
  AND token = 'cXs7FTd5ELYQ4z6la8+kRkQtp/LWTDd5qB8HZ6o3Ba0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}