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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12c1ca4b0405f372104c8305b9daacb4c3fc49ab9a553f51b95a4b63826dc250' 
  AND token = 'SDKwXaX38nI3e5qJiuKQLIbEqlJ1bEaJoz2vvX9nLQQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}