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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8a8c178a8aebffd7f68d7c3851e1a9986196c27c5e981bc044477d6f5dd861b9' 
  AND token = 'MLi8offfLuiTGkjzAno+3bUTUQeIdf19bvbUxGS9gJ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}