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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16a4703caea7d6b2494d7b04e5c660ecdb4189e4d700ee3011cf6606090d1c39' 
  AND token = 's+gUe0zUl7bT/si1Yku0rJ/lczuo/dMb8Aa2Oiuy6gE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}