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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d64e408692af45d53c6027f78889ad849fb096bbb4f24faf5d88972ff464360' 
  AND token = 'O3YayFc5FtRsfs6pOj/5y0vufHkrpn5bvNQIetT/C7Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}