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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '642a7df510115351a6c3f39867a6b6b81a08bd170b415e5f29a45160d7225171' 
  AND token = 'OH30IOjQYI3qfmdNElFk+aEBifhxVk64O9y7sd01ENM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}