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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b52d3c216f5ff4a0539dc0013eb78dbdbec71ede50e2eebe9b25a668262f11e5' 
  AND token = '/JyWRKPLLjqK1p0lEZfbCv3wRvaqvuraLQdvFwnWSi4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}