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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0d359523a67be652f58bbca3491292467f1e161ab7461f8007c451c935fb7bbc' 
  AND token = 'o3oIiJ8aJ2xG8RPtdOkYIGXA1PkW1ecrWYZBWPD4NrU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}