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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c33300211a12b4c1b0278d713497743640e2e3b5cdc69c785dbf0eb1851359a' 
  AND token = '9IEgSzo+gawSIIH10JZZrhBBEXXnNIDSvihdRnjFJ2s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}