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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53812b100548361f5b5ef7d2bb6ee68907a9ef9439e207e79bf79fb82bb09afd' 
  AND token = 'f9iGoMGMU1zdpoxVgAwMe5lxkQWe4B5l5oa1AM/td/8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}