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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '37f8834f66dd194789f130740d3f34a1bb2a77cc9aaece03d1aaa5db9e5346b0' 
  AND token = '8zVOG7D0KAmnz+qBbEKDLzNZ2PGsyVNaT47uMad2Pcw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}