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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '648763a888a9da9fa44dd4269a9ad452af4b2160e5de272477022d969dd94b6d' 
  AND token = 'jPdCkTLlCHEXM/JYwabCeBzfgWTguP7O5oU6M6Vq48I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}