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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46a6f5eb295550cf4d501e5b45a9ab3ceacd7a85a913e67e244a1f4864019ef3' 
  AND token = 'lk6HQNXeQ5FX/66PywIPpfLDLcr0F4XJPru1Fq8wzVk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}