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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81e61e3dc94658d7c952f19f923524e91764c6627a18eb2965054e8ed8b018c4' 
  AND token = '6qxZR7tyRQPMneoq//w8qFAlv6AvV3HAcdSMYSX1mRg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}