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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '490a31b44d6b1d584903fb9589fd219c8a57f96d6e53efc234c54b18699075f7' 
  AND token = 'u66PocQ2+Q8uDdW1NqwvVwDYkmuk54j0rJ4UzyYcQ7A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}