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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2ad5d22173151b6e0c05a2ed08b17cbbe812a42720933e6b3913c2c30ffdb88d' 
  AND token = 'JD7bSkuZN3/EFef7aYpGtFVJOzdBIrnBN6cOLXCvbnA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}