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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f50ec180b3a269003298b1366842018e174ff8accbe8abc3f47f529193fec687' 
  AND token = 'B74PNA8x77eWojLIheWGD3ZuLWip5xDyYd89aOUKfcQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}