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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '27c7a0a3df85886e41098edc38e5d4efe0f89bb05d181fcc65157e8d2ec4e301' 
  AND token = 'hGdAjxVTrHxSVEmHfhDenbujfxi0KjdFP5JtOj+B+J8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}