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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6af81506a93b9256c56a9d95aafcc0d0d36b94734fd945117a0e5a02d8a0c355' 
  AND token = 'AnGS4N+XzTHBPOqp9p3s/dqtyeZUW+BZ9m58wx5x4Pk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}