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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7549f772b6e8601e4ee89ea192900100280e25e4b465432533fa9efb13fcbcb8' 
  AND token = 'WcELCO6FPk/+hl5vzqu+K2dlpKMisE8psmiZTsrqbrU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}