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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '409a22a391d3410a886ad320869b11acff7b63e28eeef8e3f226dbe27ba856fc' 
  AND token = 'JfWEfSB7arTsg2Y1XVP5EiaWTLibm4BUmTDTDkUg6MA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}