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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '269777e49a7073dc44a656846a052eb0a3d47c689f9812c4e50f9263860e33a6' 
  AND token = 'HcFEckwtxQyJJPVGIHkmdX5IS+xucxJO4ozDEOe020M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}