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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e0c3d9db0f6283094f8d5c5c9785271035bf982f03afa88fd34d4ed177007345' 
  AND token = 'TIvOK/D6KwUHwYm2k8ld4JTXIYfdjT4ho9vrW9EXhB0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}