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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3f9b5b29d91d86c5a13a4fe457a3f81aac28a3b1455643fcc46c2a67887be401' 
  AND token = 'yFwdEV88EXVUEieKI1R/+h9HRyNSUCT23PHD2tQ4UJ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}