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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'df2881b00d814dbec41d2bbef0a0a0aac6d3014f0bf27ac402027457ee87c136' 
  AND token = 'VCJhQUBmBWkBhFX+s9XvIQEjdtRbJqn0otA9GX0Rj3s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}