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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12f42f8890d7a82b9193d4232564ee8d5e7f9ff9d01b4fce13372da21a280f01' 
  AND token = 'gJtdqBPvgw4L1f6KRU1DJHJM0n7Mp3XLS1V7NIdPLzo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}