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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '543cd72dd0c73441d8119fe0519c1e0a42b47eb3c7cb854c8fd2d003427c1002' 
  AND token = 'dM+JEWNB11Skse/pnX3U+cOjkNj51MU/MGCcLkxIjj0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}