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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8af0b77c229f375769a0dfeccc5ab0f385cd9b57597340989a2655bc9f1e8de3' 
  AND token = 'ywow3Zv+LmlOvDipAfV2HPlbiJdE7Lolg+kcDtCJdi8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}