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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5376d21e7a24bae728ecdfcb1fd5a5e8d06225cd2464914d0f8e08a3da204086' 
  AND token = 'OI9hbbuzukAYh7oEAFlj/Ja3Nr1e2BA/TdZgVkp+VOo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}