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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '578d776d4d8bab3e27ee225d91e20f9e3f324cef4d601650d36202e6646e9b1f' 
  AND token = '3VRCDkiJi3SQzjlrNIkdCrYspwMW0RxU8HhXyxCH+/4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}