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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4b8b78630fad8cd196b39320daea63ed17a8abda1abdce4726852d245d47acd' 
  AND token = 'ROJ0DlC5fQ9Uycyz29nfrU+/w2TB8LhKLTAs7fHnUbw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}