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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54a4a22a8211cc2dc5168f016f88b20c1e1815e05bd60e86f3ca0608c82ebeec' 
  AND token = 'sMbsDFU5IWdor+ylWKthuUWB46pvy3b+rU0bIC3KMMM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}