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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5359226ce5ad338cc30491e8a6802e2c5b4e079f41e5821efd09030bbadc6eab' 
  AND token = 'icYuNh+Fp9sBl0aoSTOZtJleKYFbDm4F4R9YRbup1eE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}