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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d40600fa52c1fbb1a61a9c1002777bcc11d490c5120eff51d491a23cccc4da2' 
  AND token = 'vt5FuGlP+hKs2MO1+BAYB9OwPrIqwRRU5LoXHgqytdo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}