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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef113f53fdb83ffb08343d080bdc1cc33ecee7c4e844394d95a9f255870a62af' 
  AND token = 'x/VyPE6x9PMoldRH5Ky8KFFv6eqeQJ+c+vd5tVjHJ0g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}