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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd5024fec1ece9d0f3bee595b455c975c0e57b901a502cecb0d8c1079eb3eefc6' 
  AND token = 'SSZioQe6HJLXgTMDpIYjekS/pYcTtvM79f7KTHxEc9Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}