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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '64b63e3e22db14553083abe1dcc5e68284f695d33d31078c3ec0d8f94151de50' 
  AND token = 'x2O4KaGjUjkj7GxKFZ1UM3pvWPAdRiG5NsEbE46Dx4E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}