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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd220c18e51631df32dec9cf3c2777cd0ae7a10d40431b0f0a8f656da61602154' 
  AND token = 'WuQeYHl7ycchlvBmjgfYIWKEboFkF3YOeko57NhY9HM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}