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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '459309c0b2b613336567cde379bdcc41599e50ea4b0028bac173f2f2dfaa11e3' 
  AND token = 'mdlCpdOfir/k/lx4icAg0LMfHPHW9YuJHE3Wl5mIwTk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}