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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10a220da1b289a6ae44d8df0dc7d6b31990ee3abeb2d5dedda1d352b7b481ded' 
  AND token = 'fkjCXgSSIz/fZmjvslvcbINlfRoM+9BoVJkb02zhXc8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}