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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59086465dc5ee2f84754e09a399c9b6c20debe47c97bc03a3f589d4975031b10' 
  AND token = 'nMJDJ6m1OOeTGpu8ceeRqJqDlSCk/HxeUBa0YKUCqI8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}