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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a16fccdf63a962adc37825426577ed2322409473d6d4a06cf25fbbe0b50e4d85' 
  AND token = 'CP/XlA+PNgDoGPan3etRAYCGpPjUGYgSBkQ5+Rn/CW4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}