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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1421574f8efefba0025d751508fa3d65183db4dc16895541820537d100f150dc' 
  AND token = 'LeaYOyLff1Dm0e1VWu+QTnmtsbPwwavalxLgqc/AI6Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}