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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c4d1d69c49f06b0a29dde78f260b1a93b95188718cf4830722e37562bf7da42f' 
  AND token = 'VCe5SPclZ1/jjNoTBzZN2OlsqNGHsAA/ErES+UUEC5A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}